ORIGINAL PAPERS:
Evaluating potential biomarkers of cachexia and survival in skeletal muscle of upper gastrointestinal cancer patients
Stephens NA, Skipworth RJE, Gallagher IJ, Greig CA, Guttridge DC, Ross JA, Fearon KCH
J Cachex Sarcopenia Muscle, 2015, Vol 6, No 1, p53-61
Programmed cell death 6 interacting protein (PDCD6IP) and Rabenosyn-5 (ZFYVE20) are potential urinary biomarkers for upper gastrointestinal cancer
Husi H, Skipworth RJ, Cronshaw A, Stephens NA, Wackerhage H, Greig C, Fearon KC, Ross JA
Proteomics Clin Appl, 2015 Jan 30
PMID 25644331
Clinical classification of cancer cachexia: phenotypic correlates in human skeletal muscle
Johns N, Hatakeyama S, Stephens NA, Degen M, Degen S, Frieauff W, Lambert C, Ross JA, Roubenoff R, Glass DJ, Jacobi C, Fearon KCH
PLoS One, 2014 Jan 3;9(1):e83618
PMID 24404136
Phase I/II trial of formoterol fumarate combined with megesterol acetate in patients with advanced malignancy
Greig CA, Johns N, Gray C, MacDonald A, Stephens NA, Skipworth RJ, Fallon M, Wall L, Fox GM, Fearon KCH
Support Care Cancer 2014 May;22(5):1269-75
PMID 24389826
The human urinary proteome fingerprint database UPdb
Husi H, Barr J, Skipworth RJE, Stephens NA, Greig CA, Wackerhage H, Barron R, Fearon KCH, Ross JA
Int J of Proteomics, 2013 760208
PMID 24222850
A novel oral tracer procedure for measurement of habitual myofibrillar protein synthesis
MacDonald AJ, Small AC, Greig CA, Husi H, Ross J, Stephens NA, Fearon KCH, Preston T
Rapid Commun in Mass Spectrom, 2013 Aug 15:27(15): 1769-77
PMID 23821570
Multiple intra-abdominal abscesses following endoluminal bariatric surgery: case report and literature review
Alanie OM, Benyounes H, Stephens NA
Surg Obes Relat Dis 2014 Jan-Feb;10(1):e1-4
PMID 23907092
Defining and treating a positive circumferential resection margin in oesophageal cancer
O’Neill JR, Stephens NA, Save V, Kamel HM, Phillips H, Driscoll PJ, Paterson-Brown S
British Journal of Surgery, 2013 Apr 24
PMID 23616367
Intrahepatic choledochoscopy during trans-cystic common bile duct exploration; technique, feasibility and value
Gough V, Stephens N, Ahmed Z, Nassar AH
Surg Endosc, 2012 May 12
PMID 22580881
Suppression of muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies
Gallagher IJ, Stephens NA*, MacDonald A, Skipworth RJ, Timmons JA, Greig C, Ross JA, Fearon KC
Clin Cancer Res, 2012 May 15;18(10):2817-27
PMID 22452944
*joint 1st author
Sexual dimorphism modulates the impact of cancer cachexia on lower limb muscle mass and function
Stephens NA, Gray C, MacDonald A, Tan BH, Gallagher IJ, Skipworth RJE, Ross JA, Fearon KCH, Greig CA
Clin Nutr, 2012 Jan 20 [Epub ahead of print]
PMID 22296872
Intramyocellular lipid droplets increase with progression of cachexia in cancer patients
Stephens NA, Skipworth RJ, Macdonald AJ, Greig CA, Ross JA, Fearon KC
J Cachex Sarcopenia Muscle, 2011 Jun 2(2):111-117
PMID 21766057
Relationship between sedentary behaviour, physical activity, muscle quality and body composition in healthy older adults
Chastin SF, Ferriolli E, Stephens NA, Fearon KC, Greig C
Age Ageing 2012 Jan;41(1):111-4
PMID 21749993
Proteomic analysis of urinary upper gastrointestinal cancer markers
Husi H, Stephens N, Cronshaw A, MacDonald A, Gallagher I, Greig C, Fearon KC, Ross JA
Proteomics Clin Appl 2011 Jun;5(5-6):289-99
PMID 21538913
This paper has attracted wide publicity from both NATIONAL AND INTERNATIONAL MEDIA
Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients
Mracek T, Stephens NA*, Gao D, Bao Y, Ross JA, Ryden M, Arner P, Trayhurn P, Fearon KC, Bing C
Br J Cancer 2011 Feb 1;104(3):441-7
PMID 21245862
*joint 1st author
Magnetic resonance imaging with k-means clustering objectively measures whole muscle volume compartments in sarcopenia/cancer cachexia
Gray C, MacGillivray TJ, Eeley C, Stephens NA, Beggs I, Fearon KC, Greig CA
Clin Nutr 2011 Feb;30(1): 106-11
PMID 20727625
Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia
Stephens NA, Gallagher IJ, Rooyackers O, Skipworth RJ, Tan BH, Marstrand T, Ross JA, Guttridge DC, Lundell L, Fearon KC, Timmons JA
Genome Med 2010 Jan 15; 2(1): 1 (Highly accessed article)
PMID 20193046
The relationship between hospital volume and post-operative mortality rates for upper gastrointestinal cancer resections: Scotland 1982-2003
Skipworth RJE, Parks RW, Stephens NA, Graham C, Irving F, Brewster DH, Garden OJ, Paterson-Brown S
European Journal of Surgical Oncology, 2010 Feb: 36(2): 141-7
PMID 19879717
Frequency of the mitochondrial DNA 4977bp deletion in oesophageal mucosa during the progression of Barrett’s oesophagus
Tan BHL, Skipworth RJE, Stephens NA, Wheelhouse NM, Gilmour H, de Beaux AC, Paterson-Brown S, Fearon KCH, Ross JA
The European Journal of Cancer 45(5): 736-740, Mar 2009
PMID 19211242
Extra-abdominal fibromatosis: A case report
Stephens N, Ahsan F, Murray DP, Hussain A, Chapman AD
Ear Nose & Throat Journal, Vol 82 (4), pp322-325, April 2003
PMID 12735165
REVIEW PAPERS:
Muscle wasting in cancer
Johns N, Stephens NA, Fearon KCH
Int J Biochem Cell Biol 2013 Oct;45 (10): 2215-29
PMID 23770121
Muscle protein kinetics in cancer cachexia
Johns N, Stephens NA, Preston T
Current Opinion in Supportive and Palliative Care, 6 (4): 417-23, Dec 2012
PMID 23123817
Cachexia, survival and the acute phase response
Stephens NA, Skipworth RJE, Fearon KCH
Current Opinion in Supportive and Palliative Care, 2: 267-274, Dec 2008
PMID 19060563
Anorexia, Cachexia and Nutrition
Stephens NA, Fearon KCH
Medicine 36,2, 2008
PUBLISHED ABSTRACTS:
Distinct age-related muscle wasting pathways are activated in samples of human cancer cachexia patients
C Jacobi, S Degen, M Degen, S Hatakeyama, N Johns, NA Stephens, JA Ross, DJ Glass, R Roubenoff, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 4, Number 4, Dec 2013, p318
PMID 24190182
Comparison of histology phenotypes and clinical classification of cancer cachexia
S Hatakeyama, N Johns, C Lambert, NA Stephens, W Frieauff, JA Ross, R Roubenoff, DJ Glass, C Jacobi, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 4, Number 4, Dec 2013, p326
PMID 24190182
Cancer cachexia: Evaluation of body composition using CT scans and identification of genetic markers
N Johns, BHL Tan, NA Stephens, TS Solheim, S Damaraju, JA Ross, S Kaasa, V Baracos, F Skorpen, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 3, Number 4, Dec 2012, p283
PMID 23180446
Defining and treating a positive circumferential resection margin in oesophageal and gastro-oesophageal junctional cancer
JR O’Neill, N Stephens, V Save, H Phillips, H Kamel, A Robertson, P Driscoll, S Paterson-Brown
Gut, 61(S2):A260, 2012
Surgical resection relinquishes suppression of skeletal muscle turnover in cancer patients
NA Stephens, IJ Gallagher, AJ MacDonald, RJE Skipworth, H Husi, CA Greig, JA Ross, JA Timmons, KCH Fearon
British Journal of Surgery Vol 99, Issue S4 Apr 2012
Skeletal muscle Akt in upper gastrointestinal cancer patients and its potential as a biomarker of cachexia
NA Stephens, IJ Gallagher, JA Ross, KCH Fearon
British Journal of Surgery Vol 99, Issue S4 Apr 2012
Phase I/II trial of formoterol fumarate combined with megestrol acetate in patients with advanced malignancy
CA Greig, C Gray, N Johns, A MacDonald, NA Stephens, L Wall, M Fallon, A Price, G Fox, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 2, Number 4, Dec 2011, p
PMID 22476871
An investigation of microRNAs in the skeletal muscle of cancer patients with cachexia
IJ Gallagher, NA Stephens*, CA Greig, JA Ross, KCH Fearon, JA Timmons
Journal of Cachexia Sarcopenia and Muscle, Volume 2, Number 4, Dec 2011, p232
*joint 1st author
PMID 22476871
Suppression of skeletal muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies
NA Stephens, IJ Gallagher, AJ MacDonald, RJE Skipworth, H Husi, CA Greig, JA Ross, JA Timmons, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 2, Number 4, Dec 2011, p231
PMID 22476871
Association of lower limb power output and functional ability in cancer cachexia
NA Stephens, KCH Fearon, CA Greig
Journal of Cachexia Sarcopenia and Muscle, Volume 2, Number 4, Dec 2011, p231
PMID 22476871
An investigation of potential skeletal muscle protein biomarkers of cancer cachexia
NA Stephens, RJE Skipworth, CA Greig, JA Ross, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 2, Number 4, Dec 2011, p216
PMID 22476871
Habitual skeletal muscle protein fractional synthetic rate in healthy individuals as determined by a novel oral tracer technique
AJ MacDonald, CA Greig, H Husi, NA Stephens, J Ross, AC Small, KCH Fearon, T Preston
Journal of Cachexia Sarcopenia and Muscle, Volume 2, Number 4, Dec 2011, p209
PMID 22476871
Impact of cancer-associated weight-loss on lower limb muscle mass and function
NA Stephens, C Gray, AJ MacDonald, BH Tan, IJ Gallagher, RJ Skipworth, JA Ross, KC Fearon, CA Greig
Clinical Nutrition, Volume 6, Supplement 1, 2011, p141
Intramyocellular lipid droplets increase with progression of cachexia in cancer patients
NA Stephens, RJ Skipworth, AJ MacDonald, CA Greig, JA Ross, KC Fearon
Clinical Nutrition, Volume 6, Supplement 1, 2011, p141
Pre-operative weight loss influences recovery following potentially curative resection in patients with upper gastrointestinal cancer
NA Stephens, AJ MacDonald, RJ Skipworth, CA Greig, KC Fearon
Clinical Nutrition, Volume 6, Supplement 1, 2011, p142
Upper and lower limb muscle mass in patients undergoing surgery for upper GI cancer
AJ MacDonald, M Esposito, C Gray, NA Stephens, C Greig, KC Fearon
Clinical Nutrition, Volume 6, Supplement 1, 2011, p42
Loss of fat free mass occurs during neoadjuvant chemotherapy for upper GI cancer
AJ MacDonald, N Stephens, M Esposito, J Ross, L Wall, C Greig, V Baracos, KC Fearon
Clinical Nutrition, Volume 6, Supplement 1, 2011, p42
Can baseline muscle mass be predicted in weight stable patients with cancer?
AJ MacDonald, N Stephens, C Greig, H Husi, KC Fearon, T Preston
Clinical Nutrition, Volume 6, Supplement 1, 2011, p41
Sarcopenic muscle shows distinct sex differences at the transcriptional level
IJ Gallagher, AJ MacDonald, NA Stephens, C Gray, H Husi, JA Ross, A Joyson, A Ratkevicius, H Wackerhage, G Miele, I Beggs, KC Fearon, C Greig
Proceedings of the Physiological Society 23, PC211, July 2011
Lack of association between Glucocorticoid Receptor and 11beta-HSD1 expression and muscle function in healthy older men and women
I Gallagher, P Hyde, N Stephens, C Gray, J Ross, K Fearon, K Chapman, C Greig
The FASEB Journal, Volume 25, Meeting Abstracts, P1049.6
Zinc-alpha2-glycoprotein in adipose atrophy in human cancer cachexia
T Mracek, NA Stephens, D Gao, X Xiao, P Trayhurn, KCH Fearon, C Bing
Journal of Cachexia Sarcopenia and Muscle, Volume 1, Number 1, Sept 2010, p51
PMID 22477519
Intramyocellular lipid content in human cancer cachexia – an ultrastructural analysis
NA Stephens, RJE Skipworth, CA Greig, JA Ross, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 1, Number 1, Sept 2010, p88
PMID 22477519
Reduced muscle quality is observed with progressive weight loss in patients with cancer
NA Stephens, C Gray, C White, BH Tan, KCH Fearon, CA Greig
Journal of Cachexia Sarcopenia and Muscle, Volume 1, Number 1, Sept 2010, p89
PMID 22477519
Elucidating the role of the ubiquitin E3 ligases and autophagy pathway in human cancer cachexia
NA Stephens, IJ Gallagher, RJE Skipworth, JA Ross, DC Guttridge, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 1, Number 1, Sept 2010, p94
PMID 22477519
Changes in circulating leptin levels and leptin gene expression in patients with cancer cachexia
T Mracek, NA Stephens, P Trayhurn, KCH Fearon, C Bing
Journal of Cachexia Sarcopenia and Muscle, Volume 1, Number 1, Sept 2010, p108
PMID 22477519
Muscle quality is associated with longer and less fragmented sedentary time in healthy older men
E Ferriolli, SFM Chastin, NA Stephens, KCH Fearon, CA Greig
Journal of Cachexia Sarcopenia and Muscle, Volume 1, Number 1, Sept 2010, p127
PMID 22477519
Human cancer cachexia – pathway analysis and identification of novel biomarkers in skeletal muscle
NA Stephens, IJ Gallagher, BH Tan, O Rooyackers, RJE Skipworth, L Lundell, JA
Ross, DC Guttridge, JA Timmons, KCH Fearon
British Journal of Surgery, Volume 97, Issue S6, Nov 2010, p5
Muscle function in cancer cachexia: Influence of systemic inflammation
NA Stephens, CD Gray, KC Fearon, CA Greig
Proceedings of the Physiological Society 14, PC48, King’s College London Human Physiology (2009)
Myosin heavy chain in human muscle wasting – an early biomarker of cancer cachexia?
NA Stephens, W He, K Guttridge, BH Tan, RJE Skipworth, CA Greig, JA Ross, KCH Fearon, DC Guttridge
Clinical Nutrition, Volume 3, Supplement 1, 2008, p91
Muscle volume and quality in weight-losing upper gastrointestinal cancer patients
NA Stephens, C Gray, C Eeley, BH Tan, KCH Fearon, CA Greig
Clinical Nutrition, Volume 3, Supplement 1, 2008, p92
Pancreas Transplantation in the new millennium
I.M. Pope, N.A. Stephens, J.J.Casey, K.K. Madhavan, S.J. Wigmore, J. Forsythe, H. Pleass and M. Akyol
Six of the Best – Transplant (Abstract)
British Journal of Surgery, Volume 90, Supplement 1, June 2003
MISCELLANEOUS:
Collaboration is needed to promote the good medicine of exercise
Murray A, Stephens N
BMJ 2015 Apr 21;350:h2057
PMID 25901013
‘Bedside Reading’ (book review – Browse’s Introduction to the Symptoms and Signs of Surgical Disease)
N.A. Stephens
Surgeons News, Issue 5.1, Jan 2006
Evaluating potential biomarkers of cachexia and survival in skeletal muscle of upper gastrointestinal cancer patients
Stephens NA, Skipworth RJE, Gallagher IJ, Greig CA, Guttridge DC, Ross JA, Fearon KCH
J Cachex Sarcopenia Muscle, 2015, Vol 6, No 1, p53-61
Programmed cell death 6 interacting protein (PDCD6IP) and Rabenosyn-5 (ZFYVE20) are potential urinary biomarkers for upper gastrointestinal cancer
Husi H, Skipworth RJ, Cronshaw A, Stephens NA, Wackerhage H, Greig C, Fearon KC, Ross JA
Proteomics Clin Appl, 2015 Jan 30
PMID 25644331
Clinical classification of cancer cachexia: phenotypic correlates in human skeletal muscle
Johns N, Hatakeyama S, Stephens NA, Degen M, Degen S, Frieauff W, Lambert C, Ross JA, Roubenoff R, Glass DJ, Jacobi C, Fearon KCH
PLoS One, 2014 Jan 3;9(1):e83618
PMID 24404136
Phase I/II trial of formoterol fumarate combined with megesterol acetate in patients with advanced malignancy
Greig CA, Johns N, Gray C, MacDonald A, Stephens NA, Skipworth RJ, Fallon M, Wall L, Fox GM, Fearon KCH
Support Care Cancer 2014 May;22(5):1269-75
PMID 24389826
The human urinary proteome fingerprint database UPdb
Husi H, Barr J, Skipworth RJE, Stephens NA, Greig CA, Wackerhage H, Barron R, Fearon KCH, Ross JA
Int J of Proteomics, 2013 760208
PMID 24222850
A novel oral tracer procedure for measurement of habitual myofibrillar protein synthesis
MacDonald AJ, Small AC, Greig CA, Husi H, Ross J, Stephens NA, Fearon KCH, Preston T
Rapid Commun in Mass Spectrom, 2013 Aug 15:27(15): 1769-77
PMID 23821570
Multiple intra-abdominal abscesses following endoluminal bariatric surgery: case report and literature review
Alanie OM, Benyounes H, Stephens NA
Surg Obes Relat Dis 2014 Jan-Feb;10(1):e1-4
PMID 23907092
Defining and treating a positive circumferential resection margin in oesophageal cancer
O’Neill JR, Stephens NA, Save V, Kamel HM, Phillips H, Driscoll PJ, Paterson-Brown S
British Journal of Surgery, 2013 Apr 24
PMID 23616367
Intrahepatic choledochoscopy during trans-cystic common bile duct exploration; technique, feasibility and value
Gough V, Stephens N, Ahmed Z, Nassar AH
Surg Endosc, 2012 May 12
PMID 22580881
Suppression of muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies
Gallagher IJ, Stephens NA*, MacDonald A, Skipworth RJ, Timmons JA, Greig C, Ross JA, Fearon KC
Clin Cancer Res, 2012 May 15;18(10):2817-27
PMID 22452944
*joint 1st author
Sexual dimorphism modulates the impact of cancer cachexia on lower limb muscle mass and function
Stephens NA, Gray C, MacDonald A, Tan BH, Gallagher IJ, Skipworth RJE, Ross JA, Fearon KCH, Greig CA
Clin Nutr, 2012 Jan 20 [Epub ahead of print]
PMID 22296872
Intramyocellular lipid droplets increase with progression of cachexia in cancer patients
Stephens NA, Skipworth RJ, Macdonald AJ, Greig CA, Ross JA, Fearon KC
J Cachex Sarcopenia Muscle, 2011 Jun 2(2):111-117
PMID 21766057
Relationship between sedentary behaviour, physical activity, muscle quality and body composition in healthy older adults
Chastin SF, Ferriolli E, Stephens NA, Fearon KC, Greig C
Age Ageing 2012 Jan;41(1):111-4
PMID 21749993
Proteomic analysis of urinary upper gastrointestinal cancer markers
Husi H, Stephens N, Cronshaw A, MacDonald A, Gallagher I, Greig C, Fearon KC, Ross JA
Proteomics Clin Appl 2011 Jun;5(5-6):289-99
PMID 21538913
This paper has attracted wide publicity from both NATIONAL AND INTERNATIONAL MEDIA
Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients
Mracek T, Stephens NA*, Gao D, Bao Y, Ross JA, Ryden M, Arner P, Trayhurn P, Fearon KC, Bing C
Br J Cancer 2011 Feb 1;104(3):441-7
PMID 21245862
*joint 1st author
Magnetic resonance imaging with k-means clustering objectively measures whole muscle volume compartments in sarcopenia/cancer cachexia
Gray C, MacGillivray TJ, Eeley C, Stephens NA, Beggs I, Fearon KC, Greig CA
Clin Nutr 2011 Feb;30(1): 106-11
PMID 20727625
Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia
Stephens NA, Gallagher IJ, Rooyackers O, Skipworth RJ, Tan BH, Marstrand T, Ross JA, Guttridge DC, Lundell L, Fearon KC, Timmons JA
Genome Med 2010 Jan 15; 2(1): 1 (Highly accessed article)
PMID 20193046
The relationship between hospital volume and post-operative mortality rates for upper gastrointestinal cancer resections: Scotland 1982-2003
Skipworth RJE, Parks RW, Stephens NA, Graham C, Irving F, Brewster DH, Garden OJ, Paterson-Brown S
European Journal of Surgical Oncology, 2010 Feb: 36(2): 141-7
PMID 19879717
Frequency of the mitochondrial DNA 4977bp deletion in oesophageal mucosa during the progression of Barrett’s oesophagus
Tan BHL, Skipworth RJE, Stephens NA, Wheelhouse NM, Gilmour H, de Beaux AC, Paterson-Brown S, Fearon KCH, Ross JA
The European Journal of Cancer 45(5): 736-740, Mar 2009
PMID 19211242
Extra-abdominal fibromatosis: A case report
Stephens N, Ahsan F, Murray DP, Hussain A, Chapman AD
Ear Nose & Throat Journal, Vol 82 (4), pp322-325, April 2003
PMID 12735165
REVIEW PAPERS:
Muscle wasting in cancer
Johns N, Stephens NA, Fearon KCH
Int J Biochem Cell Biol 2013 Oct;45 (10): 2215-29
PMID 23770121
Muscle protein kinetics in cancer cachexia
Johns N, Stephens NA, Preston T
Current Opinion in Supportive and Palliative Care, 6 (4): 417-23, Dec 2012
PMID 23123817
Cachexia, survival and the acute phase response
Stephens NA, Skipworth RJE, Fearon KCH
Current Opinion in Supportive and Palliative Care, 2: 267-274, Dec 2008
PMID 19060563
Anorexia, Cachexia and Nutrition
Stephens NA, Fearon KCH
Medicine 36,2, 2008
PUBLISHED ABSTRACTS:
Distinct age-related muscle wasting pathways are activated in samples of human cancer cachexia patients
C Jacobi, S Degen, M Degen, S Hatakeyama, N Johns, NA Stephens, JA Ross, DJ Glass, R Roubenoff, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 4, Number 4, Dec 2013, p318
PMID 24190182
Comparison of histology phenotypes and clinical classification of cancer cachexia
S Hatakeyama, N Johns, C Lambert, NA Stephens, W Frieauff, JA Ross, R Roubenoff, DJ Glass, C Jacobi, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 4, Number 4, Dec 2013, p326
PMID 24190182
Cancer cachexia: Evaluation of body composition using CT scans and identification of genetic markers
N Johns, BHL Tan, NA Stephens, TS Solheim, S Damaraju, JA Ross, S Kaasa, V Baracos, F Skorpen, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 3, Number 4, Dec 2012, p283
PMID 23180446
Defining and treating a positive circumferential resection margin in oesophageal and gastro-oesophageal junctional cancer
JR O’Neill, N Stephens, V Save, H Phillips, H Kamel, A Robertson, P Driscoll, S Paterson-Brown
Gut, 61(S2):A260, 2012
Surgical resection relinquishes suppression of skeletal muscle turnover in cancer patients
NA Stephens, IJ Gallagher, AJ MacDonald, RJE Skipworth, H Husi, CA Greig, JA Ross, JA Timmons, KCH Fearon
British Journal of Surgery Vol 99, Issue S4 Apr 2012
Skeletal muscle Akt in upper gastrointestinal cancer patients and its potential as a biomarker of cachexia
NA Stephens, IJ Gallagher, JA Ross, KCH Fearon
British Journal of Surgery Vol 99, Issue S4 Apr 2012
Phase I/II trial of formoterol fumarate combined with megestrol acetate in patients with advanced malignancy
CA Greig, C Gray, N Johns, A MacDonald, NA Stephens, L Wall, M Fallon, A Price, G Fox, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 2, Number 4, Dec 2011, p
PMID 22476871
An investigation of microRNAs in the skeletal muscle of cancer patients with cachexia
IJ Gallagher, NA Stephens*, CA Greig, JA Ross, KCH Fearon, JA Timmons
Journal of Cachexia Sarcopenia and Muscle, Volume 2, Number 4, Dec 2011, p232
*joint 1st author
PMID 22476871
Suppression of skeletal muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies
NA Stephens, IJ Gallagher, AJ MacDonald, RJE Skipworth, H Husi, CA Greig, JA Ross, JA Timmons, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 2, Number 4, Dec 2011, p231
PMID 22476871
Association of lower limb power output and functional ability in cancer cachexia
NA Stephens, KCH Fearon, CA Greig
Journal of Cachexia Sarcopenia and Muscle, Volume 2, Number 4, Dec 2011, p231
PMID 22476871
An investigation of potential skeletal muscle protein biomarkers of cancer cachexia
NA Stephens, RJE Skipworth, CA Greig, JA Ross, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 2, Number 4, Dec 2011, p216
PMID 22476871
Habitual skeletal muscle protein fractional synthetic rate in healthy individuals as determined by a novel oral tracer technique
AJ MacDonald, CA Greig, H Husi, NA Stephens, J Ross, AC Small, KCH Fearon, T Preston
Journal of Cachexia Sarcopenia and Muscle, Volume 2, Number 4, Dec 2011, p209
PMID 22476871
Impact of cancer-associated weight-loss on lower limb muscle mass and function
NA Stephens, C Gray, AJ MacDonald, BH Tan, IJ Gallagher, RJ Skipworth, JA Ross, KC Fearon, CA Greig
Clinical Nutrition, Volume 6, Supplement 1, 2011, p141
Intramyocellular lipid droplets increase with progression of cachexia in cancer patients
NA Stephens, RJ Skipworth, AJ MacDonald, CA Greig, JA Ross, KC Fearon
Clinical Nutrition, Volume 6, Supplement 1, 2011, p141
Pre-operative weight loss influences recovery following potentially curative resection in patients with upper gastrointestinal cancer
NA Stephens, AJ MacDonald, RJ Skipworth, CA Greig, KC Fearon
Clinical Nutrition, Volume 6, Supplement 1, 2011, p142
Upper and lower limb muscle mass in patients undergoing surgery for upper GI cancer
AJ MacDonald, M Esposito, C Gray, NA Stephens, C Greig, KC Fearon
Clinical Nutrition, Volume 6, Supplement 1, 2011, p42
Loss of fat free mass occurs during neoadjuvant chemotherapy for upper GI cancer
AJ MacDonald, N Stephens, M Esposito, J Ross, L Wall, C Greig, V Baracos, KC Fearon
Clinical Nutrition, Volume 6, Supplement 1, 2011, p42
Can baseline muscle mass be predicted in weight stable patients with cancer?
AJ MacDonald, N Stephens, C Greig, H Husi, KC Fearon, T Preston
Clinical Nutrition, Volume 6, Supplement 1, 2011, p41
Sarcopenic muscle shows distinct sex differences at the transcriptional level
IJ Gallagher, AJ MacDonald, NA Stephens, C Gray, H Husi, JA Ross, A Joyson, A Ratkevicius, H Wackerhage, G Miele, I Beggs, KC Fearon, C Greig
Proceedings of the Physiological Society 23, PC211, July 2011
Lack of association between Glucocorticoid Receptor and 11beta-HSD1 expression and muscle function in healthy older men and women
I Gallagher, P Hyde, N Stephens, C Gray, J Ross, K Fearon, K Chapman, C Greig
The FASEB Journal, Volume 25, Meeting Abstracts, P1049.6
Zinc-alpha2-glycoprotein in adipose atrophy in human cancer cachexia
T Mracek, NA Stephens, D Gao, X Xiao, P Trayhurn, KCH Fearon, C Bing
Journal of Cachexia Sarcopenia and Muscle, Volume 1, Number 1, Sept 2010, p51
PMID 22477519
Intramyocellular lipid content in human cancer cachexia – an ultrastructural analysis
NA Stephens, RJE Skipworth, CA Greig, JA Ross, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 1, Number 1, Sept 2010, p88
PMID 22477519
Reduced muscle quality is observed with progressive weight loss in patients with cancer
NA Stephens, C Gray, C White, BH Tan, KCH Fearon, CA Greig
Journal of Cachexia Sarcopenia and Muscle, Volume 1, Number 1, Sept 2010, p89
PMID 22477519
Elucidating the role of the ubiquitin E3 ligases and autophagy pathway in human cancer cachexia
NA Stephens, IJ Gallagher, RJE Skipworth, JA Ross, DC Guttridge, KCH Fearon
Journal of Cachexia Sarcopenia and Muscle, Volume 1, Number 1, Sept 2010, p94
PMID 22477519
Changes in circulating leptin levels and leptin gene expression in patients with cancer cachexia
T Mracek, NA Stephens, P Trayhurn, KCH Fearon, C Bing
Journal of Cachexia Sarcopenia and Muscle, Volume 1, Number 1, Sept 2010, p108
PMID 22477519
Muscle quality is associated with longer and less fragmented sedentary time in healthy older men
E Ferriolli, SFM Chastin, NA Stephens, KCH Fearon, CA Greig
Journal of Cachexia Sarcopenia and Muscle, Volume 1, Number 1, Sept 2010, p127
PMID 22477519
Human cancer cachexia – pathway analysis and identification of novel biomarkers in skeletal muscle
NA Stephens, IJ Gallagher, BH Tan, O Rooyackers, RJE Skipworth, L Lundell, JA
Ross, DC Guttridge, JA Timmons, KCH Fearon
British Journal of Surgery, Volume 97, Issue S6, Nov 2010, p5
Muscle function in cancer cachexia: Influence of systemic inflammation
NA Stephens, CD Gray, KC Fearon, CA Greig
Proceedings of the Physiological Society 14, PC48, King’s College London Human Physiology (2009)
Myosin heavy chain in human muscle wasting – an early biomarker of cancer cachexia?
NA Stephens, W He, K Guttridge, BH Tan, RJE Skipworth, CA Greig, JA Ross, KCH Fearon, DC Guttridge
Clinical Nutrition, Volume 3, Supplement 1, 2008, p91
Muscle volume and quality in weight-losing upper gastrointestinal cancer patients
NA Stephens, C Gray, C Eeley, BH Tan, KCH Fearon, CA Greig
Clinical Nutrition, Volume 3, Supplement 1, 2008, p92
Pancreas Transplantation in the new millennium
I.M. Pope, N.A. Stephens, J.J.Casey, K.K. Madhavan, S.J. Wigmore, J. Forsythe, H. Pleass and M. Akyol
Six of the Best – Transplant (Abstract)
British Journal of Surgery, Volume 90, Supplement 1, June 2003
MISCELLANEOUS:
Collaboration is needed to promote the good medicine of exercise
Murray A, Stephens N
BMJ 2015 Apr 21;350:h2057
PMID 25901013
‘Bedside Reading’ (book review – Browse’s Introduction to the Symptoms and Signs of Surgical Disease)
N.A. Stephens
Surgeons News, Issue 5.1, Jan 2006